흰쥐 악하선에서 배설관 폐쇄에 따른 나트륨 운반체 발현의 변화
Altered Expression of sodium Transporters in the Excretory Duct
구강과학- 전남대학교 2003년 15권 4호 p.289 ~ 298
오유근, 유선열,
소속 상세정보
오유근 ( ) - 전남대학교 치의학연구소, 전남대학교
유선열 ( ) - 전남대학교 치의학연구소, 전남대학교
KMID : 0988420030150040289
Abstract
Although acinar atrophy frequently occurs and the salivary secretory activity is significantly decreased in various salivary glandular diseases, their underlying molecular mechanisms have not been established.
The present study was aimed to increase our understanding of functional alterations associated with pathological acinar atrophy.
Male Sprague-Dawley rats weighing 180-200g were used.
Their left submandibular ducts were ligated for 1 week, and the expression of sodium transporters related to the salivary formation was determined in the gland. The ligated gland was significantly decreased in its weight.
The expressions of α_(1) and β_(1) subunits of Na, K-pump determined by Western blot analysis were increased in the experimental group.
Accordingly, the catalytic activity of Na, K-pump was increased.
The expressions of α, β, and γ subunits of BNaC were increased. The expression of TSC was also increased. The mRNA expression of mineralocorticoid receptor determined by reverse transcription-polymerase chain reaction was decreased in the experimental group.
These results suggest that the changes in sodium transporters are causally related with an increased intraluminal pressure in the salivary duct in the ligated gland.
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